Tegolasen Intermediates CAS NO1270294-05-7|(R)-5,7-difluorochroman-4-ol Manufacture Price

Uses: (R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].

Production Methods: Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].