product Name |
S-3-hydroxytetrahydrofuran |
Synonyms |
(S)-(+)-3-Hydroxytetrahydrofuran; S(+)-3-hydroxyTetrahydrofuran; (S)-3-Hydroxytetrahydrofuran; (S)-tetrahydrofuran-3-ol; (3S)-tetrahydrofuran-3-ol; Hydroxytetrahydrofuran, (S)-(+)-3-; Thiophene-3-ol,tetrahydro-, (S)-; Thiophene-3-ol,tetrahydro-, (3S)-; (S)-(+)-tetrahyro-3-furanol; (S)-Tetrahydro-Furan-3-ol; (s)-(+)-tetrahydro-3-furanol; 2-Furanyl,tetrahydro-3-hydroxy-, (R)- |
Molecular Formula |
C4H8O2 |
Molecular Weight |
88.1051 |
InChI |
InChI=1/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2/t4-/m0/s1 |
CAS Registry Number |
86087-23-2;79107-75-8;84976-47-6 |
Molecular Structure |
|
Density |
1.148g/cm3 |
Boiling point |
181°C at 760 mmHg |
Refractive index |
1.475 |
Flash point |
81.1°C |
Water solubility |
soluble |
Vapour Pressur |
0.255mmHg at 25°C |
Description |
(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs. |
Uses |
1.(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.
2.(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents. |
Raw materials |
Ethanol–>Ethyl acetate–>Methanol–>Tetrahydrofuran–>Toluene–>Lithium Aluminum Hydride–>p-Toluenesulfonic acid–>L-Malic acid |
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