Lapatinib intermediates

Organic Intermediate Supply High purity 104458-24-4 | 2-Aminoethylmethylsulfone hydrochloride

Categories: Anti-tumor intermediates, Pharmaceutical Intermediates Tags: Anti-tumor intermediates, Lapatinib intermediates

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product Name	2-Aminoethylmethylsulfone hydrochloride
Synonyms	2-(Methylsulfony)ethylamine hydrochloride; 2-(methylsulfonyl)ethanamine hydrochloride; 2-aminoethylmethyl sulfone HCL; 2-(Methylsulfonyl)Ethylamine HCl; 2-(methylsulfonyl)ethanamine hydrochloride (1:1); 2-(Methylsulfonyl)-ethanamine hydrochloride; 2-(Methylsulfonyl)ethylamine hydrochloride; 2-Aminoethylmethylsulfone HCl; 2-Methanesulfonyl-ethylamine; hydrochloride
Molecular Formula	C₃H₁₀ClNO₂S
Molecular Weight	159.635
InChI	InChI=1/C3H9NO2S.ClH/c1-7(5,6)3-2-4;/h2-4H2,1H3;1H
CAS Registry Number	104458-24-4
Molecular Structure
Boiling point	325.8°C at 760 mmHg
Flash point	150.8°C
Vapour Pressur	0.000163mmHg at 25°C
Description	Lapatinib is a new drug targeted for the treatment of breast cancer developed by GlaxoSmithKline, which was approved for marketing by the US Food and Drug Administration on March 13, 2007. The currently approved indications are advanced mastocarcinoma treated with lapatinib and capecitabine or metastatic breast cancer, and breast cancer patients must be treated first in other first-class drugs. Its trade name is Tykerb in the United States. On December 14, 2007, the European Medicines Agency (EMEA) approved for marketing of lapatinib in Europe, and the trade name is Tyverb. Breast cancer molecular targeted therapy is the treatment for oncogene related with occurrence and development of breast cancer, and for its related expression product. Molecular targeted drugs control the changes of gene expression in the cell through blocking signal transduction of tumor cell or related cell, thereby inhibiting or killing tumor cells. Lapatinib is a small molecule epidermal growth factor tyrosine kinase inhibitor orally. Clinical trials have shown that lapatinib has a very good clinical effect in patients with HER2 breast cancer who have been resistant to Roche’s Herceptin. In vitro, the inhibitory effect of lapatinib on the growth of Her-2 overexpressing breast cancer cell lines was significant. Lapatinib is also highly effective in the Phase I clinical trial of Her-2 overexpression in advanced breast cancer and has no cross-resistance with Herceptin (trastuzumab). Unlike Herceptin (trastuzumab), its structure is small molecules, so it could get through the blood-brain barrier, thereby having a certain therapeutic effect for breast cancer brain metastases.
Chemical Properties	Off-white to yellow solid
Uses	2-(Methylsulfonyl)ethylamine Hydrochloride is used in the synthetic preparation of potent and selective PI3Kδ inhibitors.

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