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Factory supply Intermediate 6494-19-5 | 3-Methyl-6-nitroindazole

Categories: Anti-tumor intermediates, Pharmaceutical Intermediates Tags: Anti-tumor intermediates, Pazopanib intermediates

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product Name	3-Methyl-6-nitroindazole
Synonyms	3-Methyl-6-nitro-1H-indazole; 3-methyl-6-nitro-3H-indazole; 3-Methyl-6-Nitro-1H-Indozole; 3-Methyl-6-Nifro-1H-Indazole
Molecular Formula	C₈H₇N₃O₂
Molecular Weight	177.1601
InChI	InChI=1/C8H7N3O2/c1-5-7-3-2-6(11(12)13)4-8(7)10-9-5/h2-5H,1H3
CAS Registry Number	6494-19-5
Molecular Structure
Density	1.49g/cm³
Melting point	187-188℃
Boiling point	279.4°C at 760 mmHg
Refractive index	1.704
Flash point	122.8°C
Vapour Pressur	0.00684mmHg at 25°C
Description	3-Methyl-6-nitroindazole is an important organic reagent or pharmaceutical intermediate compound used in the preparation of key intermediates of pazopanib. In experimental studies, it is mostly used for solubility determination, correlation and molecular interaction analysis studies in different pure and mixed solvents. The results showed that in the temperature range of (278.15 ~ 328.15)K, the molar fraction solubility of 3-Methyl-6-nitroindazole increased with increasing temperature in both pure and mixed solvent systems, and was maximum in pure N, N-dimethylformamide and minimum in water.
Chemical Properties	Brown solid
References	[1] Li, Wanxin et al. “3-Methyl-6-nitroindazole in some aqueous co-solvent mixtures: Solubility determination, preferential solvation and solvent effect analysis.” The Journal of Chemical Thermodynamics 34 1 (2020): 0. [2] Li Wang. “Solubility Measurement, Correlation, and Molecular Interactions of 3-Methyl-6-nitroindazole in Different Neat Solvents and Mixed Solvents from T = 278.15 to 328.15 K.” Journal of Chemical & Engineering Data 64 8 (2019): 3260–3269.

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