Factory supply Intermediate |51067-38-0| 4-Phenoxyphenyl boronic acid

product Name	4-Phenoxyphenyl boronic acid
CAS No	51067-38-0
Synonyms	4-Phenoxybenzene boronic acid;
Molecular Formula	C₁₂H₁₁BO₃
Molecular Weight	214.0249
InChI	InChI=1/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H
Molecular Structure
Density	1.23g/cm³
Melting point	141-145℃
Boiling point	377°C at 760 mmHg
Refractive index	1.605
Flash point	181.8°C
Vapour Pressur	2.36E-06mmHg at 25°C
Chemical Properties	white to off-white powder and chunk
Uses	1.suzuki reaction 2. 4-Phenoxybenzeneboronic Acid is an intermediate used to prepare biphenyl derivatives of nitotrifluoromethoxybenzyloxydihydroimidazooxazines with antitubercular activity. It is also used in the synthesis of pyrrolo pyrimidines as potent inhibitors of Lck kinase. 3.4-Phenoxyphenylboronic acid can be used as a reactant: In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst. To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions. To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.

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