Pazopanib intermediates

Excellent Chemical Intermediates 635702-64-6 Pazopanib Hydrochloride From China Supplier

Categories: Anti-tumor intermediates, Pharmaceutical Intermediates Tags: Anti-tumor intermediates, Pazopanib intermediates

Description
Reviews (0)

product Name	Pazopanib Hydrochloride
Synonyms	5-((4-((2,3-Dimethyl-2H-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide monohydrochloride; Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-,monohydrochloride; GW786034B; UNII-33Y9ANM545; Votrient; Pazopanib HCl; 5-(4-((2,3-dimethyl-2H-indazol-6-yl)(Methyl)amino)pyrimidin-2-ylamino)-2-Methylbenzenesulfonamide hydrochloride
Molecular Weight	473.9866
InChI	InChI=1/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
CAS Registry Number	635702-64-6
Molecular Structure
Description	Pazopanib Hydrochloride is the hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is an oral second-generation multitarget TKI developed by GSK and approved for marketing by the FDA in 2009 and the EMA in 2010. It targets the VEGFR, platelet-derived growth factor receptor, and c-kit, key proteins responsible for tumor growth and survival. It is used to treat patients with advanced RCC and advanced soft tissue sarcoma who have experienced chemotherapy. Pazopanib Hydrochloride has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, a tyrosine kinase inhibitor, and an angiogenesis-modulating agent.
Uses	1. Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. 2.Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively 3. The Hydrochloride salt of Pazopanib (P210925) a oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Reviews

There are no reviews yet.

Be the first to review “Excellent Chemical Intermediates 635702-64-6 Pazopanib Hydrochloride From China Supplier”