Excellent Chemical Intermediates |151266-23-8|4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidine

product Name	4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidine
CAS No	151266-23-8
Synonyms	3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-; 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine; 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Formula	C₅H₄IN₅
Molecular Weight	261.02
Molecular Structure
Uses	3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Synthesis	A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).

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