Crizotinib Intermediates CAS NO1032900-25-6|Ceritinib (LDK378) Factory Supply Pure Chemical Intermediate

Description: Ceritinib (previously LDK378l, brand name Zykadia; Novartis Pharmaceuticals) is an oral small molecule tyrosine kinase inhibitor of ALK [87]. Preclinical studies suggested that it would inhibit ROS1 as well [88, 89].

Uses: 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.

Clinical Use: ALK-inhibitor:
                         Treatment of anaplastic lymphoma kinase (ALK)- positive advanced non-small cell lung cancer                            (NSCLC) previously treated with crizotinib