| product Name |
N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine |
| Synonyms |
N-(2-chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-Indazol-6-amine |
| Molecular Formula |
C14H14ClN5 |
| Molecular Weight |
287.7475 |
| InChI |
InChI=1/C14H14ClN5/c1-9-11-5-4-10(8-12(11)18-20(9)3)19(2)13-6-7-16-14(15)17-13/h4-8H,1-3H3 |
| CAS Registry Number |
444731-75-3 |
| Molecular Structure |
|
| Density |
1.339g/cm3 |
| Boiling point |
524.447°C at 760 mmHg |
| Refractive index |
1.673 |
| Flash point |
270.976°C |
| Vapour Pressur |
0mmHg at 25°C |
| Chemical Properties |
Light Beige to Beige Solid |
| Uses |
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR. |
| Safety Description |
A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%). |
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