| product Name |
2-(4-Fluorophenyl)thiophene |
| Synonyms |
2-(4-Fluorphenyl)thiophen; T5SJ BR DF [WLN]; Thiophene, 2-(4-fluorophenyl)-; 2-(4-Fluorophenyl) thiophene |
| Molecular Formula |
C10H7FS |
| Molecular Weight |
178.226 |
| InChI |
InChI=1/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H |
| CAS Registry Number |
58861-48-6 |
| Molecular Structure |
|
| Density |
1.201g/cm3 |
| Boiling point |
252.316°C at 760 mmHg |
| Refractive index |
1.578 |
| Flash point |
106.397°C |
| Vapour Pressur |
0.031mmHg at 25°C |
| Uses |
2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. |
| Synthesis |
4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene. |
| Preparation Products |
5-(4-Fluorophenyl)thiophene-2-carboxylic acid–>(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone |
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