product Name |
Doxifluridine |
Synonyms |
5′-Deoxy-5-fluorouridine; 5′-DFUR; (2xi)-5′-deoxy-5-fluorouridine; 5-Fluoro-5′-deoxyuridine |
Molecular Formula |
C9H11FN2O5 |
Molecular Weight |
246.1924 |
InChI |
InChI=1/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6?,8?/m1/s1 |
CAS Registry Number |
3094-09-5 |
EINECS |
221-440-1 |
Molecular Structure |
|
Density |
1.63g/cm3 |
Refractive index |
1.605 |
Hazard Symbols |
|
Description |
Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers. |
Uses |
1. A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity
2. An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
3. 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
4. antineoplastic, pyrimidine antimetabolite |
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