| product Name | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester |
|---|---|
| Molecular Formula | C21H14BrClFN3O |
| Molecular Weight | 458.71 |
| CAS Registry Number | 641569-97-3 |
| Molecular Structure | ![641569-97-3 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester](https://images-a.chemnet.com/suppliers/chembase/cas261/641569-97-3.gif)
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| Uses | 1.4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic Acid Ethyl Ester-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib, which might be useful in treatment of chronic myelogenous leukemia.
2. Ethyl 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoate is used in preparation of the Smo inhibitor and synthesis and their application. |
| Description | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester is a pharmaceutical intermediate compound used in the preparation of nilotinib, a transactivation inhibitor targeting BCR-ABL, c-kit, and PDGF, which is used in the treatment of a variety of leukaemia, including chronic granulocytic leukaemia (CML). Chronic granulocytic leukaemia (CML) is caused by the BCR-ABL oncogene. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. |
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